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NSW Public Health Bulletin archive

Does intradermal hepatitus B vaccine work? Volume 2 Issue 10

Peter Christopher, Anne Richards, John Williams, Jack Buist, Gail Osborne

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About the author/s

Peter Christopher

Anne Richards

John Williams

Jack Buist

Gail Osborne


The hepatitis B vaccine used in NSW is of the recombinant or genetically engineered type. The genetic material within the DNA of the hepatitis B virus was initially cloned into the DNA of Escherichia coli, enabling the isolation of the S-gene and its incorporation into an expression plasmid containing the components necessary for replication and maintenance in yeast cells.